Determinations of the urinary pregnanetriol according to the modified Bongiovanni´s method were made in 5 normally menstruating women, 6 climacteric women, 6 castrated women, 64 pregnant women; 4 hirsute women and a case of adrenocortical tumor.
Pregnant women comprised 37 cases with normal pregnancy, 5 cases in .labor and puerperium, 5 cases with hyperemesis gravidarum, 7 cases with spontaneous abortion, 5 cases with premature labor and 5 cases with toxemia of pregnancy.
The following results were obtained:
1) A method for determination of pregnanetriol was presented. The method was reproducible with adequate recoveries and. reasonably convenient for clinical use; Recovery average 79,9?1.1 per cent.
2) The urinary pregnanetriol levels of the normally menstruating women were as follows; 0.42±0.10
mg/day in the follicular phase and 1.00±0.32 mg/day in the luteal phase.
3) The urinary pregnanetriol levels of the climacteric women were 0:38±0.04 mg/day.
4) The urinary pregnanetriol levels, determined in the castrated :women to investigate effects of castration on the excretion of pregnanetriol,, showed a statistically significant decrease on the postoperative tenth day.
There was no significant statistical difference between the urinary pregnanetriol levels of the castrated women and the climacteric women on the postoperative fifteenth day.
5) In normal pregnancy extending from the second month to the term of gestation the excretion of pregnanetriol was significantly higher than that in non-pregnant women. This elevation began about the second month of gestation.
The excretion then decreased to a low value at the fourth month and again increased to a maximum. at the term of gestation.
The urinary pregnanetriol levels in normal pregnancy were as follows; the second month: 1.38±0.15 mg/day the third month: 1.63±0.24 mg/day
the fourth month: 1.22±0.23 rng/day
the fifth month: 1.75±0.32 mg/day
the sixth month: 1.97±0.39 mg/day
the seventh month: 2.48±0.36 mg/day
the eighth month: 2.83±0.14 mg/day
the ninth month: 3.12±0.48 mg/day
the -tenth month: 3.32±0.44 mg/day
|